Endocrine Abstracts

Background: A major challenge in the management of breast cancer (BC) is the search for biomarkers that are sensitive and less invasive. miRNAs are reported to be tissue-specific, stable and aberrantly expressed in different tumours, hence their emerging role as potential biomarkers in BC management.Objective: The study focused on developing an in-house method for the detection of mir-145 and mir-21 using SYBR Gre...

Background: A major challenge in the management of breast cancer (BC) is the search for biomarkers that are sensitive and less invasive. miRNAs are reported to be tissue-specific, stable and aberrantly expressed in different tumours, hence their emerging role as potential biomarkers in BC management.Objective: The study focused on developing an in-house method for the detection of mir-145 and mir-21 using SYBR Gre...

Breast cancer is the most frequent carcinoma in women and its prevalence could be reduced by early detection which can improve the chances of successful treatment and recovery. Post transcriptional genetic modifiers known as microRNAs (miRNAs) are widely believed to play an essential role in many malignancies, acting as either tumor suppressors or oncogenes. Many recent studies on breast cancer have analyzed various miRNAs that may influence breast cancer progression and devel...

The use of herbal intervention in the treatment of tumors is widely spread in all regions of the developing world even though there are insufficient data on their possible molecular mechanism of action. Thirty percent of all cancers in women occur in the breast making it the most commonly diagnosed female cancer. The cytotoxic properties of the 80% aqueous-ethanol crude, n-hexane, chloroform, ethylacetate, detannified, and tannin fractions of Curculigo pilosa&#146...

The prevalence of new cases of cancer in developing countries even though less than the developed countries have greater mortality rate, due to lack of access to treatment and early detection of the disease. Epigenetic alterations in BRCA2 and TP53, such as DNA methylation, maybe an effective approach in diagnosis, prognosis and therapy in breast cancer. This study examines the DNA methylation signature of BRCA2 and TP53 in Nigerian breast cancer patients. In this study, thirt...